I work in pharma, regularly writing and filing things with the FDA (and other agencies), and this has been a topic of conversation at work. The good news for people is that the EMA is still a thing in the EU. So, at least the large pharma companies (like the one I work for), are likely to not really change much about their quality control/processes/etc. because we will still need to conform to the EMA guidelines which are typically in line with the current FDA (sometimes more strict, sometimes less so). The real quality concern would be smaller companies that only file for products in the US. They would only need to meet whatever new FDA guidelines come into effect (if they even do, changing stuff like GMP guidance is extremely complicated and time consuming) since the US is their only market.

Don’t overthink it. I bend the rules in my communities quite often. The case that happens most often is somebody posting a duplicate of a news story. However, it is usually one or more days later and the new post usually picks up some comments from new people that didn’t comment on the previous post. I often let those slide. As long as people are trying to constructively engage in the community, then I give people the benefit of the doubt.

That style does work well for presentations

I honestly prefer presentations to writing for the reasons you pointed out. I have never been too nervous when it comes to public speaking, and I feel much more able to convey my point through a more conversational style. However, my presentation style (specifically slide design) has had to change a lot over the course of my career.

When I was in grad school, my preferred method of presentation was to have a slide with a single graph/image/diagram on it and then verbally talk through all the things I wanted to convey for that slide. It allowed me tons of flexibility, kept the slides from becoming cluttered and distracting, and created a more conversational atmosphere as people felt more empowered to ask questions as I was going (this also helps keep the audience engaged).

However, as I moved into a professional setting, I had a mentor sit me down and tell me how great my presentations were, but they were not really effective in a corporate setting like this one (global company, split across timezones, etc). The simple reason being that the slides I was making were being shared to others who couldn’t make it to my presentation and a good chunk of the actual audience of the presentation only ever got to see the slides, without the benefit of my talking to help them understand. So, this has led me to move more towards including text on my slides. I basically have to ask myself if there is enough information on this slide to understand things without my explaining it, but without anything extra to make it confusing.

Since the pandemic, I have also had to change things up a bit to make presentations more amenable to presenting via Teams/Zoom. This means things like removing videos, complex animation, or any audio. It just doesn’t work reliably enough through screen sharing and if you can find a way around it, then it makes everybody’s life easier.

Speaking of tangents, this has been a long one, but I care a lot about effective communication and specifically presentations. So many people are so bad at giving a good presentation, and I find it frustrating personally, when I have to sit through so many.

I actually agree with you about math education and math texts. It is really bad at conveying understanding and my math-heavy courses were the toughest for me (E&M in grad school was awful). Too often math textbooks simply present things and leave the proof as an exercise for the reader, or they will lean too far the other way and present formal proofs for everything. Either way is not helpful for developing an intuitive understanding of what is going on.

The things that helped me develop communication skills the most were simply doing it a lot followed by having some good mentors that I found to be good communicators. My grad school advisor was great at communicating physics and one of my early bosses in industry was an excellent presenter. So, I would often bounce either writing or slides off of them for feedback.

I am guilty of writing walls of text as comments, but I try to stick to my lane. You can see my most recent wall of text about freeze dryers as an example. There are a few things that I think need to come together to create a good, high-effort post:

• Passion - If you don’t care, you aren’t going to spend the time to write about something
• Knowledge - For some topics this may be less required, but I tend to create walls of text about technical issues. I have a PhD in physics, so that gives me a pretty good foundation of knowledge to work from in this regard
• Writing Ability - You need to be able to write effectively to make a wall of text worthwhile. This is a skill that gets better the more you do it.

The other thing I tend to do when writing a high-effort post is I actually proofread it before making it. I try to cut out unneeded tangents, reword things that might be confusing, or supplement things that aren’t motivated enough.

For me personally, this doesn’t take me too long to do since I have been writing and presenting about extremely technical topics for about two decades at this point. Like I mentioned above, informative writing is a skill that gets better with practice. So, doing it regularly as a significant part of my job as well as providing feedback to others on their writing/presentations, has provided me with tons of practice to improve these things.

If you want some formal guidance on scientific writing/presentations specifically, two books I have found informative (mostly on presentations) have been:

• The Craft of Scientific Presentations by Michael Alley
• slide:ology - The Art and Science of Creating Great Presentations by Nancy Duarte

This is mine too. I use the hell out of it and YouTube music that comes with it. If we look at $/hr, then this is a no-brainer for me.

I consume quite a bit of anime and manga (just look at the communities I moderate), and I see a number of regular complaints about translation in that space. I personally think most of them are overblown and that translators are doing their best. Translation is far from a science and almost every sentence/paragraph has judgement calls that need to be made by the translator. What some people find annoying about a translation might make the work more approachable to somebody else.

One thing that does bother me for Japanese is the exclusion of honorifics. Most subtitles these days include them, which is a definite improvement over official subs of the past. In subtitle form, honorifics are usually the only indication that a speaker is using something like formal language (keigo) unless you have some knowledge of the spoken language.

As a bit of an aside, if you are interested in professional translation and some of the challenges they face (especially with MTL on the horizon), then Anime Herald did an interview with several of them. Check it out!

I have hosted a wordpress site on my unraid box before, but ended up moving it to a VPS instead. I ended up moving it primarily because a VPS is just going to have more uptime since I end up tinkering around with my homelab too often. So, any service that I expect other people to use, I often end up moving it to a VPS (mostly wikis for different things). The one exception to that is anything related to media delivery (plex, jellyfin, *arr stack), because I don’t want to make that as publicly accessible and it needs close integration with the storage array in unraid.

The fraud surrounding Alzheimer’s research continues… Not too long ago the fraud was related to amyloid (archive version). That article was even written by the same author and features many of the same investigators.

I work in Pharma R&D (on the manufacturing side) and the company I work for has run trials for Alzheimer’s products based on research that has since been found to be fraudulent. As a published scientist myself, I would like to think that this level of manipulation and fabrication is the exception rather than the rule. However, I do think it is worth asking at this point what it is about Alzheimer’s research in particular that has led to this being so prevalent and, more importantly, so impactful. Basically, how did it go so far before anything was caught?

I suspect at least part of the answer is due to the large influx of money into the field. Researchers were tripping over themselves to earn those grants and then, once they had them, produce results to keep them. I am not in academia, so I don’t have great insight into the NIH, NIA or their processes, but this should be a wake up call to put up a certain amount of guard rails.

Boston and New York are probably the closest to European cities with respect to transit that you will find in the States. Plenty of people live in those cities without cars. I lived in Boston for a long time (now in the Boston suburbs) and plenty of adults I know there haven’t even bothered getting their driver’s license.

The other Northeast Corridor cities are probably the next tier down. DC has decent transit if you make live and work near transit stops. Philadelphia can work, but SEPTA has been unreliable at best in my personal experience. I haven’t really spent much time in Baltimore to be able to say.

Outside of the Northeast Corridor, the only other option really would be the San Francisco bay area with its BART system. It has decent coverage and I have family that lives in the area and enjoys it. However, I don’t have much firsthand experience with it.

There is a lot of collaboration between the different instance admins in this regard. The lemmy.world admins have a matrix room that is chock full of other instance admins where they share bots that they find to help do things like find similar posters and set up filters to block things like spammy urls. The nice thing about it all is that I am not an admin, but because it is a public room, anybody can sit in there and see the discussion in real time. Compare that to corporate social media like reddit or facebook where there is zero transparency.

This is what I do. I have a VPS that handles all the 443 traffic and then proxies it back to my home server on the correct port. I also just serve some things directly from the VPS since I have it already. It also works well to have a second box for things like uptime monitoring.

Thanks for the clarification!

I am guessing a large portion of those might be inactive accounts as well. When the reddit exodus was at its peak, there were definite issues with the way 2FA worked in lemmy. I think it got reset at one point due to changes made in subsequent lemmy versions and users had to re-enable it.

Some good answers in here already. It boils down to a couple points for me:

• Back when I started selfhosting, it was either nginx or apache, and I found nginx better and easier to set up
• All the nginx knowledge I learned years ago still works just the same as it did back then, so why potentially mess things up by switching if it all still works
• Basically every project has an example nginx config for reference, that can’t be said about other proxies
• It is easier to find support online for edge cases that might pop up with nginx due to the ubiquity of its use and years of history

Intel confirmed on reddit that oxidation did impact some chips.

More than one thing can be wrong at the same time, so everybody can be right!

I didn’t have a VPS with them, but long ago I had a couple domains through them. One of them had an issue with the auto-renewal and I never got a notification of any kind, only finding out when they had taken ownership of the domain, advertising it for sale. Then they wanted some way, way higher amount of money for me to buy it back. So, I don’t have any domains with them any more.

This was years and years ago though, so they might be better now.

Everybody’s pager went off in celebration!

I use Sonarr, but it does mess up sometimes for shows even when you mark it as an anime to use absolute numbering. It most often happens with older shows that have lots of OVAs that are sometimes listed as episodes and sometimes listed as specials, depending on the database. So, if you are having Sonarr manage your downloads, then it can grab the wrong episode if its database (I think TVDB) and the release (usually using MAL numbering) disagree.

I don’t have a solution for you, but I will be watching this thread. Currently, I use Sonarr for library organization, but it doesn’t always work well with anime due to title differences and differences between how seasons/specials are numbered in different databases. So, Shoko was on my radar to try out at some point since it uses anidb.